Some landmark papers in resilience research

A few examples of landmark papers in resilience research – empirical, methodological, conceptual – presented at past symposia before publication or initiated at a past symposium meeting through discussions among participants.

Ayash S, Lingner T, Ramisch A, Ryu S, Kalisch R, Schmitt U, Müller MB (2025) Fear circuit-based neurobehavioral signatures mirror resilience to chronic social stress in mouse. Proc Natl Acad Sci U S A. 120(17):e2205576120. doi: 10.1073/pnas.2205576120

Ahrens KF, Schenk C, Kollmann B, Puhlmann LMC, Neumann RJ, Schäfer SK, Reis D, Basten U, Weichert D, Fiebach CJ, Lutz B, Wessa M, Repple J, Lieb K, Tüscher O, Reif A, Kalisch R, Plichta MM (2024) Resilience to major life events: Advancing trajectory modeling and resilience factor identification by controlling for background stressor exposure. Am Psychol. 79(8):1076–1091. doi: 10.1037/amp0001315

Kaldewaij R, Koch SBJ, Hashemi MM, Zhang W, Klumpers F, Roelofs K (2021) Anterior prefrontal brain activity during emotion control predicts resilience to post-traumatic stress symptoms. Nat Hum Behav. 5(8):1055-1064. doi: 10.1038/s41562-021-01055-2

Stevens JS, Harnett NG, Lebois LAM, van Rooij SJH, Ely TD, Roeckner A, Vincent N, Beaudoin FL, An X, Zeng D, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Rauch SL, Lewandowski C, Storrow AB, Hendry PL, Sheikh S, Musey PI Jr, Haran JP, Jones CW, Punches BE, Lyons MS, Kurz MC, McGrath ME, Pascual JL, Datner EM, Chang AM, Pearson C, Peak DA, Domeier RM, O'Neil BJ, Rathlev NK, Sanchez LD, Pietrzak RH, Joormann J, Barch DM, Pizzagalli DA, Sheridan JF, Luna B, Harte SE, Elliott JM, Murty VP, Jovanovic T, Bruce SE, House SL, Kessler RC, Koenen KC, McLean SA, Ressler KJ (2021) Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma. Am J Psychiatry. 178(11):1037-1049. doi: 10.1176/appi.ajp.2021.20101526

Gee DG (2021) Early Adversity and Development: Parsing Heterogeneity and Identifying Pathways of Risk and Resilience. Am J Psychiatry. 178(11):998-1013. doi: 10.1176/appi.ajp.2021.21090944

Schultebraucks K, Shalev AY, Michopoulos V, Grudzen CR, Shin SM, Stevens JS, Maples-Keller JL, Jovanovic T, Bonanno GA, Rothbaum BO, Marmar CR, Nemeroff CB, Ressler KJ, Galatzer-Levy IR (2020) A validated predictive algorithm of post-traumatic stress course following emergency department admission after a traumatic stressor. Nat Med. 1084-1088. doi: 10.1038/s41591-020-0951-z

Dudek KA, Dion-Albert L, Lebel M, LeClair K, Labrecque S, Tuck E, Ferrer Perez C, Golden SA, Tamminga C, Turecki G, Mechawar N, Russo SJ, Menard C (2020) Molecular adaptations of the blood-brain barrier promote stress resilience vs. depression. Proc Natl Acad Sci U S A. 117(6):3326-3336. doi: 10.1073/pnas.1914655117

Ungar M, Theron L (2020) Resilience and mental health: how multisystemic processes contribute to positive outcomes. Lancet Psychiatry. 7(5):441-448. doi: 10.1016/S2215-0366(19)30434-1

Cruz-Pereira JS, Rea K, Nolan YM, O'Leary OF, Dinan TG, Cryan JF (2019) Depression's Unholy Trinity: Dysregulated Stress, Immunity, and the Microbiome. Annu Rev Psychol. 71:49-78. doi: 10.1146/annurev-psych-122216-011613

Kalisch R, Cramer AOJ, Binder H, Fritz J, Leertouwer I, Lunansky G, Meyer B, Timmer J, Veer IM, van Harmelen AL (2019) Deconstructing and Reconstructing Resilience: A Dynamic Network Approach. Perspect Psychol Sci. 2019 Sep;14(5):765-777. doi: 10.1177/1745691619855637

Choi KW, Stein MB, Dunn EC, Koenen KC, Smoller JW (2019) Genomics and psychological resilience: a research agenda. Mol Psychiatry. 24(12):1770-1778. doi: 10.1038/s41380-019-0457-6

de Chaumont F, Ey E, Torquet N, Lagache T, Dallongeville S, Imbert A, Legou T, Le Sourd AM, Faure P, Bourgeron T, Olivo-Marin JC (2019) Real-time analysis of the behaviour of groups of mice via a depth-sensing camera and machine learning. Nat Biomed Eng. 3(11):930-942. doi: 10.1038/s41551-019-0396-1

Singh-Taylor A, Molet J, Jiang S, Korosi A, Bolton JL, Noam Y, Simeone K, Cope J, Chen Y, Mortazavi A, Baram TZ (2018) NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience. Mol Psychiatry. 23(3):648-657. doi: 10.1038/mp.2016.240

Richter-Levin G, Stork O, Schmidt MV (2019) Animal models of PTSD: a challenge to be met. Mol Psychiatry. 24(8):1135-1156. doi: 10.1038/s41380-018-0272-5

Anacker C, Luna VM, Stevens GS, Millette A, Shores R, Jimenez JC, Chen B, Hen R (2018) Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus. Nature. 559(7712):98-102. doi: 10.1038/s41586-018-0262-4

Gerlicher AMV, Tüscher O, Kalisch R (2018) Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction. Nat Commun. 9(1):4294. doi: 10.1038/s41467-018-06785-y

Menard C, Pfau ML, Hodes GE, Kana V, Wang VX, Bouchard S, Takahashi A, Flanigan ME, Aleyasin H, LeClair KB, Janssen WG, Labonté B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga C, Turecki G, Campbell M, Fayad ZA, Tang CY, Merad M, Russo SJ (2017) Social stress induces neurovascular pathology promoting depression. Nat Neurosci. 20(12):1752-1760. doi: 10.1038/s41593-017-0010-3

Kalisch R, Baker DG, Basten U, Boks MP, Bonanno GA, Brummelman E, Chmitorz A, Fernàndez G, Fiebach CJ, Galatzer-Levy I, Geuze E, Groppa S, Helmreich I, Hendler T, Hermans EJ, Jovanovic T, Kubiak T, Lieb K, Lutz B, Müller MB, Murray RJ, Nievergelt CM, Reif A, Roelofs K, Rutten BPF, Sander D, Schick A, Tüscher O, Diest IV, Harmelen AV, Veer IM, Vermetten E, Vinkers CH, Wager TD, Walter H, Wessa M, Wibral M, Kleim B (2017) The resilience framework as a strategy to combat stress-related disorders. Nat Hum Behav. 1(11):784-790. doi: 10.1038/s41562-017-0200-8

Shemesh Y, Forkosh O, Mahn M, Anpilov S, Sztainberg Y, Manashirov S, Shlapobersky T, Elliott E, Tabouy L, Ezra G, Adler ES, Ben-Efraim YJ, Gil S, Kuperman Y, Haramati S, Dine J, Eder M, Deussing JM, Schneidman E, Yizhar O, Chen A (2017). Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics. Nat Neurosci. 19(11):1489-1496. doi: 10.1038/nn.4346

Houtepen LC, Vinkers CH, Carrillo-Roa T, Hiemstra M, van Lier PA, Meeus W, Branje S, Heim CM, Nemeroff CB, Mill J, Schalkwyk LC, Creyghton MP, Kahn RS, Joëls M, Binder EB, Boks MP (2016) Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans. Nat Commun. 7:10967. doi: 10.1038/ncomms10967